Celiac Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Celiac Disease, including details on symptoms, diagnosis, causes, diet.

Prevalence of celiac disease in a cohort of women with unexplained infertility.

Jackson JE, Rosen M, McLean T, Moro J, Croughan M, Cedars MI

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of California at San Francisco, San Francisco, California, USA.

Several European studies have suggested a higher prevalence of celiac disease (CD) among infertile women (4% to 8%) compared with the general population (<1%). We screened a cohort of women with unexplained infertility in Northern California for the serum markers of CD, tissue transglutaminase and endomysium antibodies (EMA). Given that only one woman out of 121 (0.8%) screened positive for CD, it appears that CD is about as prevalent in this cohort of infertile women as in the general U.S. population (<1%).

Published 14 April 2008 in Fertil Steril, 89(4): 1002-4.
Full-text of this article is available online (may require subscription).

Articles on Celiac Disease published 8 April 2008:

Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis.   Gastroenterology, 134(4): 1017-27.

BACKGROUND & AIMS: The extensive infiltration of CD8(+) T cells in the intestinal mucosa of celiac disease (CD) patients is a hallmark of the disease. We identified a gliadin peptide (pA2) that is selectively recognized by CD8(+) T cells infiltrating intestinal mucosa of HLA-A2(+) CD patients. Herein, we investigated the phenotype, the tissue localization, and the effector mechanism of cells responsive to pA2 by using the organ culture of CD intestinal mucosa. The target of pA2-mediated ... [Abstract] [Full-text]

Articles on Celiac Disease published 4 April 2008:

Comparative usefulness of deamidated gliadin antibodies in the diagnosis of celiac disease.   Clin Gastroenterol Hepatol, 6(4): 426-32; quiz 370.

BACKGROUND & AIMS: Serologic tests are used frequently in celiac disease diagnosis. Gliadin antibodies generally lack the accuracy required for proper diagnosis. We evaluated the value of deamidated gliadin antibody measurements in the diagnosis and follow-up evaluation of celiac disease and compared their potential usefulness with that of gliadin and tissue-transglutaminase antibodies. METHODS: We tested deamidated gliadin, gliadin, and tissue-transglutaminase-immunoglobulin (Ig)A and -IgG ... [Abstract] [Full-text]

Articles on Celiac Disease published 2 April 2008:

Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association.   J Med Genet, 45(4): 222-7.

BACKGROUND: Coeliac disease is caused by dietary gluten, which triggers chronic inflammation of the small intestine in genetically predisposed individuals. In one quarter of the patients the disease manifests in the skin as dermatitis herpetiformis. Recently, a novel candidate gene, myosin IXB on chromosome 19p13, was shown to be associated with coeliac disease in the Dutch and Spanish populations. The same gene has previously been associated with inflammatory bowel disease, systemic lupus ... [Abstract] [Full-text]

Articles on Celiac Disease published 27 March 2008:

Newly identified genetic risk variants for celiac disease related to the immune response.   Nat Genet, 40(4): 395-402.

Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in an additional 1,643 cases and 3,406 controls. Through joint analysis including the genome-wide association study data (767 cases, 1,422 controls), we identified seven previously unknown risk regions (P < 5 x 10(-7)). Six regions harbor genes controlling immune responses, ... [Abstract] [Full-text]

Articles on Celiac Disease published 12 March 2008:

Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis.   Gut, 57(4): 463-7.

BACKGROUND: Coeliac disease (gluten-sensitive enteropathy; GSE) and inflammatory bowel disease (IBD) are common gastrointestinal disorders. Both display enhanced intestinal permeability, initiated by gluten exposure (GSE) or bacterial interactions (IBD). Previous studies showed the association of both diseases with variants in MYO9B, presumably involved in epithelial permeability. AIM: It was hypothesised that genetic variants in tight junction genes might affect epithelial barrier function, ... [Abstract] [Full-text]

Articles on Celiac Disease published 7 March 2008:

Combined functional and positional gene information for the identification of susceptibility variants in celiac disease.   Gastroenterology, 134(3): 738-46.

BACKGROUND & AIMS: Celiac disease is a complex, immune-mediated disorder of the intestinal mucosa with a strong genetic component. HLA-DQ2 is the major determinant of risk, but other minor genes, still to be identified, also are involved. METHODS: We designed a strategy that combines gene expression profiling of intestinal biopsy specimens, linkage region information, and different bioinformatics tools for the selection of potentially regulatory single-nucleotide polymorphisms (SNPs) ... [Abstract] [Full-text]

Articles on Celiac Disease published 27 February 2008:

Advances in coeliac disease.   Curr Opin Gastroenterol, 24(2): 129-34.

PURPOSE OF REVIEW: The number of people diagnosed with coeliac disease continues to rise, and this article critically summarizes recent research into the condition. RECENT FINDINGS: Much work has been focused on clarifying the molecular pathways involving cytokines in coeliac disease. Such work will yield improved understanding of the complex pathogenesis of coeliac disease and novel therapeutic targets. SUMMARY: The recent literature predominantly focuses on both elucidating the pathogenesis ... [Abstract] [Full-text]

Coeliac disease: a biopsy is not always necessary for diagnosis.   Aliment Pharmacol Ther, 27(7): 572-7.

BACKGROUND: In view of the high diagnostic accuracy of immunoglobulin-A-tissue transglutaminase antibodies for detecting coeliac disease, we have explored whether a small bowel biopsy is always required to establish the diagnosis. AIM: To define the transglutaminase antibody level giving a positive predictive value for coeliac disease of 100% and to subsequently assess the proportion of new diagnoses of coeliac disease having such a result. METHODS: The Celikey kit (Phadia GmbH, Frieburg, ... [Abstract] [Full-text]

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