Celiac Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Celiac Disease, including details on symptoms, diagnosis, causes, diet.

Celiac disease is not a risk factor for infertility in men.

Zugna D, Richiardi L, Akre O, Stephansson O, Ludvigsson JF

Cancer Epidemiology Unit, Center for Experimental Research and Medical Studies and Center for Oncologic Prevention in Piedmont, University of Turin, Turin, Italy.

Published 22 March 2011 in Fertil Steril, 95(5): 1709-13.e1-3.
Full-text of this article is available online (may require subscription).

Articles on Celiac Disease published 10 March 2011:

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.   Nature, 471(7337): 220-4.

Under physiological conditions the gut-associated lymphoid tissues not only prevent the induction of a local inflammatory immune response, but also induce systemic tolerance to fed antigens. A notable exception is coeliac disease, where genetically susceptible individuals expressing human leukocyte antigen (HLA) HLA-DQ2 or HLA-DQ8 molecules develop inflammatory T-cell and antibody responses against dietary gluten, a protein present in wheat. The mechanisms underlying this dysregulated mucosal ... [Abstract] [Full-text]

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.   Nature, 471(7337): 220-4.

Under physiological conditions the gut-associated lymphoid tissues not only prevent the induction of a local inflammatory immune response, but also induce systemic tolerance to fed antigens. A notable exception is coeliac disease, where genetically susceptible individuals expressing human leukocyte antigen (HLA) HLA-DQ2 or HLA-DQ8 molecules develop inflammatory T-cell and antibody responses against dietary gluten, a protein present in wheat. The mechanisms underlying this dysregulated mucosal ... [Abstract] [Full-text]

Articles on Celiac Disease published 14 February 2011:

Compliance with the gluten-free diet: the role of locus of control in celiac disease.   J Pediatr, 158(3): 463-466.e5.

[Abstract] [Full-text]

Articles on Celiac Disease published 8 February 2011:

Fast and efficient characterization of an anti-gliadin monoclonal antibody epitope related to celiac disease using resin-bound peptides.   J Immunol Methods, 365(1): 174-82.

Celiac disease is a permanent intolerance to gluten. A strong indication for celiac disease is the presence of antibodies specific for gliadin, a main component of gluten. Using a deamidated immunogenic gliadin fragment, corresponding to amino acid residues 58-73 (LQPFPQPQLPYPQPQ) of gliadin a monoclonal anti-gliadin antibody has previously been generated. In this study we present an alternative approach for fast and efficient epitope mapping of the monoclonal anti-gliadin antibody, using ... [Abstract] [Full-text]

Fast and efficient characterization of an anti-gliadin monoclonal antibody epitope related to celiac disease using resin-bound peptides.   J Immunol Methods, 365(1): 174-82.

Celiac disease is a permanent intolerance to gluten. A strong indication for celiac disease is the presence of antibodies specific for gliadin, a main component of gluten. Using a deamidated immunogenic gliadin fragment, corresponding to amino acid residues 58-73 (LQPFPQPQLPYPQPQ) of gliadin a monoclonal anti-gliadin antibody has previously been generated. In this study we present an alternative approach for fast and efficient epitope mapping of the monoclonal anti-gliadin antibody, using ... [Abstract] [Full-text]

Articles on Celiac Disease published 2 February 2011:

Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease.   Immunology, 132(3): 432-40.

The autoimmune enteropathy, coeliac disease (CD), is triggered by ingestion of gluten-containing grains. We recently reported that the chemokine receptor CXCR3 serves as a receptor for specific gliadin peptides that cause zonulin release and subsequent increase in intestinal permeability. To explore the role of CXCR3 in the immune response to gliadin, peripheral blood mononuclear cells from both patients with CD and healthy controls were incubated with either pepsin-trypsin-digested gliadin or ... [Abstract] [Full-text]

Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease.   Immunology, 132(3): 432-40.

The autoimmune enteropathy, coeliac disease (CD), is triggered by ingestion of gluten-containing grains. We recently reported that the chemokine receptor CXCR3 serves as a receptor for specific gliadin peptides that cause zonulin release and subsequent increase in intestinal permeability. To explore the role of CXCR3 in the immune response to gliadin, peripheral blood mononuclear cells from both patients with CD and healthy controls were incubated with either pepsin-trypsin-digested gliadin or ... [Abstract] [Full-text]

Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease.   Immunology, 132(3): 432-40.

The autoimmune enteropathy, coeliac disease (CD), is triggered by ingestion of gluten-containing grains. We recently reported that the chemokine receptor CXCR3 serves as a receptor for specific gliadin peptides that cause zonulin release and subsequent increase in intestinal permeability. To explore the role of CXCR3 in the immune response to gliadin, peripheral blood mononuclear cells from both patients with CD and healthy controls were incubated with either pepsin-trypsin-digested gliadin or ... [Abstract] [Full-text]

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