Celiac Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Celiac Disease, including details on symptoms, diagnosis, causes, diet.

Mechanisms underlying celiac disease and its neurologic manifestations.

Green PH, Alaedini A, Sander HW, Brannagan TH, Latov N, Chin RL

Department of Medicine and Celiac Disease Center, College of Physicians and Surgeons, Columbia University, New York 10022, USA.

The extra-intestinal manifestations of celiac disease (CD), including ataxia and peripheral neuropathy, are increasingly being recognized as the presenting symptoms of this autoimmune disease. Although there is a greater understanding of the pathogenesis of the intestinal lesions in CD the mechanisms behind the neurologic manifestations of CD have not been elucidated. In this article, the authors review the cellular and molecular mechanisms behind the histopathologic changes in the intestine, discuss the presentation and characteristics of neurologic manifestations of CD, review the data on the mechanisms behind these manifestations, and discuss the diagnosis and treatment of CD. Molecular mimicry and intermolecular help may play a role in the development of neurologic complications.

Published 3 May 2005 in Cell Mol Life Sci, 62(7): 791-9.
Full-text of this article is available online (may require subscription).

© 2005-2008 Celiac Disease Research Today. All Rights Reserved.